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作者用瑟利德米(Thalidomide)成功治愈1例骨髓移植后的急性移植与宿主病(GVHD)患者。患者,男性,34岁,患有B细胞型急性淋巴细胞性白血病,经接受人类淋巴细胞抗原系统—变性反应(HLA-CR)同孢兄弟的骨髓移植(BmT)后首次病情转归。BmT前2天,开始静滴环胞霉素以预防移植物抗宿主疾病(GVHD)。第8天患者发生高血压,用一种β-阻滞剂治疗,11天出现Ⅱ级皮肤GVHD,无肝脏或胃肠道受累的证据。乃予以甲基强的松治疗
The authors successfully treated 1 patient with acute graft versus host disease (GVHD) following bone marrow transplantation with Thalidomide. The patient, male, 34 years old with B-cell acute lymphoblastic leukemia, had his first condition after bone marrow transplantation (BmT) of the same-sex brother who had received human lymphocyte antigen-system degeneration (HLA-CR). Two days prior to BmT, intravenous cyclosporine was started to prevent graft-versus-host disease (GVHD). Patients developed hypertension on day 8, treated with a beta-blocker, and grade II grade GVHD on day 11 with no evidence of liver or gastrointestinal involvement. Is given methyl prednisone treatment