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近10年来,生物治疗在类风湿性关节炎中取得了很大的进步,然而这种治疗因其昂贵不良反应大而且需要反复注射而受到很大限制,而基因治疗则避免了这些缺点,选择性高,能稳定作用到靶基因,已在在动物实验中得到证实,但临床实验还处在起步阶段。本文就1,基因转移载体、2,细胞因子转移基因治疗、3,组织修复及组织破坏因子的转基因治疗、4,细胞凋亡基因的转基因治疗;做一个综述,以方便专业医疗工作者了解其进展。
Biotherapy has made great strides in rheumatoid arthritis in the last 10 years. However, this treatment is limited by its high cost and the need for repeated injections, and gene therapy avoids these shortcomings. High sex, can stabilize the target gene, has been confirmed in animal experiments, but clinical trials are still in its infancy. In this paper, 1, gene transfer vector, 2, cytokine gene therapy, 3, tissue repair and tissue destruction factor of the transgenic treatment, 4, genetically modified apoptotic gene therapy; to make a review to facilitate professional medical workers to understand their progress.