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目前,肿瘤化疗所用的大多数药物,都是经动物移植性肿瘤试验而被发现的,临床使用的抗肿瘤化合物对移植性动物肿瘤均有作用,可见移植性肿瘤是筛选抗肿瘤新药最常用的模型。其优点是接种一定量瘤细胞或无细胞滤液(病毒性肿瘤)后,可以使一群动物带有同样的肿瘤,生长速率较一致,接种成活率近100%。对各别宿主的影响相似,故易于客观判断疗效,且可在同种或同品系动物中连续移植,长期保留供试验之用,试验周期较短。
At present, most of the drugs used in cancer chemotherapy have been discovered through animal transplantable tumor tests. The antitumor compounds used clinically have effects on transplanted animal tumors, showing that transplantable tumors are the most commonly used anti-tumor drugs for screening. model. The advantage is that after inoculation of a certain amount of tumor cells or cell-free filtrate (viral tumor), a group of animals can have the same tumor, the growth rate is relatively uniform, and the survival rate of inoculation is nearly 100%. The effects on each host are similar, so it is easy to judge the curative effect objectively, and it can be continuously transplanted in the same species or the same strain animal, and it is reserved for the test for a long time. The test period is short.