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作者曾报道两个家族高甲状腺素血症是由于血清蛋白结合T_4增多而造成的,显示常染色体显性遗传。患者血清游离甲状腺素水平是正常的,但游离FT_4指数却异常增高。作者进一步证实了起主要作用的血清蛋白是白蛋白部分,并认为T_4结合白蛋白成分(TBA)仅存在于高甲状腺素血症患者,因此命名为“家族性异常白蛋白的高甲状腺素血症”。本文作者报告并提出这种TBA也有可能出现在正常血清中。
The authors have reported that both familial hyperhypothyrexemia are caused by an increase in serum protein binding T_4, indicating autosomal dominant inheritance. Patients with serum free thyroxine levels are normal, but the free FT_4 index was abnormally increased. The authors further confirm that the predominant serum albumin is the albumin moiety and that the T_4 binding albumin component (TBA) is only present in patients with hyperhypothyrexemia and is therefore named “Hyperhyphypophthalmia with familial abnormal albumin ”. The authors report and suggest that this TBA may also appear in normal serum.