肝肺综合征是在慢性肝病、门静脉高压症的基础上,由多种因素共同参与、相互作用而导致低氧血症,肺血管扩张的一种疾病。肝肺综合征的发病机制较复杂且不完全明确,但气体信号分子参与了肺血管张力调节,并导致肺血管扩张。肝肺综合征预后差,严重威胁患者身体健康,积极有效地研究和防治肝肺综合征具有重要意义。本文就气体信号分子在肝肺综合征发病机制中的作用作一综述。 Hepatopulmonary syndrome is a chronic liver disease, portal hypertension based on the multiple factors involved in the interaction, resulting in hypoxemia, pulmonary vasodilation of a disease. The pathogenesis of hepatopulmonary syndrome is more complex and not completely clear, but the gas signaling molecules are involved in pulmonary vascular tone regulation and lead to pulmonary vasodilation. The poor prognosis of hepatopulmonary syndrome, a serious threat to the patient’s health, active and effective research and prevention and treatment of hepatopulmonary syndrome is of great significance. This article reviews the role of gas signaling molecules in the pathogenesis of hepatopulmonary syndrome.