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目的通过本研究,比较早期糖尿病肾病(DN)、高血压肾病(HRD)、狼疮肾病(LN)、健康人群胱抑素C(Cys-C)、肌酐(Scr)、尿微量白蛋白(mAlb)及尿微量白蛋白肌酐比值(mAlb/Scr)的变化,以探讨其临床应用价值。方法 45例健康体检者(A组),46例早期DN(B组),40例早期HRD(C组),28例LN(D组),检测4组Cys-C、Scr、mAlb及mAlb/Scr水平,并对其相关性进行分析。结果 A组与B、C、D组比较各项均有显著差异(P<0.01)。B组与C组mAlb有显著差异(P<0.01),Cys-C、mAlb/Scr有差异(P<0.05),Scr无统计学意义(P>0.05)。B组与D组mAlb有差异(P<0.05),Cys-C、Scr、mAlb/Scr无统计学意义(P>0.05)。C组与D组Cys-C、mAlb/Scr有统计学意义。结论 Cys-C、mAlb、Scr及mAlb/Scr联合检验对准确诊断早期继发性肾损害有较高临床意义,研究还发现早期DN及LN较HRD肾损害更为严重。
Objective To compare the effects of early diabetic nephropathy (DN), hypertensive nephropathy (HRD), lupus nephropathy (LN), healthy subjects such as cystatin C (Cys-C), creatinine (Scr) and urine microalbumin (mAlb) And urinary albumin creatinine ratio (mAlb / Scr) changes to explore its clinical value. Methods Forty five healthy subjects (group A), 46 early DN (group B), 40 early HRD (group C) and 28 LN (group D) were enrolled in this study. Cys-C, Scr, mAlb and mAlb / Scr levels, and analyze their relevance. Results There was significant difference between group A and group B, C and D (P <0.01). There were significant differences in mAlb between group B and group C (P <0.01), Cys-C and mAlb / Scr (P <0.05), and Scr had no statistical significance (P> 0.05). There was no significant difference of mAlb between group B and group D (P <0.05), but there was no significant difference of Cys-C, Scr and mAlb / Scr (P> 0.05). Cys-C and mAlb / Scr in group C and group D were statistically significant. Conclusion The combination of Cys-C, mAlb, Scr and mAlb / Scr test has a high clinical value for the accurate diagnosis of early secondary renal damage. The study also found that renal damage in early DN and LN was more serious than HRD.