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目的 探讨纳洛酮早期干预治疗重度新生儿缺氧缺血性脑病的疗效。方法 重度新生儿缺氧缺血性脑病患儿63例,随机分为治疗组35例,对照组28例,两组均采用统一的常规综合治疗,在此基础上,治疗组加用纳洛酮注射液。结果 治疗组治疗呼吸衰竭、循环不良及肌张力恢复的总有效率分别为88.6%、91.4%和82.9%;对照组总有效率分别为46.4%、50.0%和42.9%,经统计学处理,二组有显著性差异:P<0.01。结论 对重度新生儿缺氧缺血性脑病,在常规综合治疗基础上应用纳洛酮早期干预,与对照组相比,呼吸衰竭、循环不良及肌张力恢复快,治愈率高,效果显著。
Objective To investigate the effect of naloxone early intervention on severe neonatal hypoxic-ischemic encephalopathy. Methods Sixty-three children with severe neonatal hypoxic-ischemic encephalopathy were randomly divided into treatment group (n = 35) and control group (n = 28). Both groups were treated by the same conventional combination therapy. On the basis of this, Injection. Results The total effective rate of treatment group was 88.6%, 91.4% and 82.9% respectively. The total effective rate of control group was 46.4%, 50.0% and 42.9% respectively. After treatment, Group had significant difference: P <0.01. Conclusion In severe neonatal hypoxic-ischemic encephalopathy, naloxone is used as early intervention on the basis of conventional comprehensive therapy. Compared with the control group, respiratory failure, poor circulation and recovery of muscle tone are rapid and the cure rate is high.