抗结核药乙胺丁醇的许多合成路线,绝大多数须通过其关键中间体2-氨基丁醇(Ⅰ)。后者的各种制备途径,除氨基丁酸等少数方法外。所得均属混旋体;拆分后剩下的左旋体D-I尚未找到较理想的消旋化方法,是为本产品的难题之一。国外L-I的价格较DL-I贵3倍,看来主要也是这个原因。 The vast majority of many synthetic routes to the anti-tuberculosis drug ethambutol must pass through its key intermediate, 2-aminobutanol (I). The latter preparation of various ways, in addition to a small number of methods such as aminobutyric acid. The resulting is a mixed body; after the separation of the left body D-I has not yet found a more ideal racemization method is one of the problems for this product. Foreign L-I is three times more expensive than the DL-I, it seems mainly for this reason.