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目的 探讨原发性单纯乳腺鳞状细胞癌的临床病理特点和治疗方法。方法 对 12例原发性单纯乳腺鳞状细胞癌患者的临床病理资料进行回顾性分析。结果 全部患者均以乳腺单发肿块为首发症状 ,肿块最大直径为 2 .5～ 10 .0cm。均行手术治疗 ,术后按照美国癌症联合委员会 (AJCC)与国际抗癌联盟 (UICC)联合制定的TNM分期标准分期 ,Ⅱa 期 6例 ,Ⅱb 期 2例 ,Ⅲa 期 2例 ,Ⅲb 期 2例。 10例患者有随访资料 ,平均随访时间 5 4 .2个月 ,6例存活 ,4例死亡。结论 原发性单纯乳腺鳞状细胞癌在大多数情况下诊断采用排除其他癌的方法 ,最初可从穿刺细胞学诊断中得到提示。目前尚无规范性的治疗方案 ,预后评价不一。
Objective To investigate the clinicopathological features and treatment of primary simple breast squamous cell carcinoma. Methods The clinical data of 12 patients with primary simple squamous cell carcinoma of the breast were retrospectively analyzed. Results All patients were single breast mass as the first symptom, the largest diameter of the tumor was 2.5 ~ 10 .0 cm. All patients underwent surgical treatment. According to the TNM staging standard jointly established by the American Joint Commission on Cancer (AJCC) and the International Union Against Cancer (UICC), there were 6 cases of stage Ⅱa, 2 cases of stage Ⅱb, 2 cases of stage Ⅲa and 2 cases of stage Ⅲb . Ten patients had follow-up data. The average follow-up time was 54.2 months. Six patients survived and four died. Conclusions In most cases, primary simple breast squamous cell carcinoma is diagnosed by a method that excludes other cancers and is initially suggested by the biopsy diagnosis. There is no normative treatment, the prognosis is not the same.