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目的观察酒精型消化溃疡患者采用兰索拉唑和奥美拉唑治疗的临床效果。方法选取医院收治的酒精型消化溃疡患者108例,按随机数字表法分为米索拉唑组合奥美拉唑组各54例。兰索拉唑组采用克拉霉素、阿莫西林以及兰索拉唑治疗,奥美拉唑组采用克拉霉素、阿莫西林以及奥美拉唑治疗。比较2组临床效果。结果兰索拉唑组总有效率为96.30%高于奥美拉唑组的87.04%(P<0.05)。兰索拉唑组Hp清除率为90.74%高于奥美拉唑组的77.78%(P<0.05)。兰索拉唑组不良反应发生率为3.70%低于奥美拉唑组的12.96%(P<0.05)。结论兰索拉唑治疗酒精型消化溃疡效果显著,Hp清除率较高,临床症状明显改善,且安全性较高,值得临床应用及推广。
Objective To observe the clinical effects of lansoprazole and omeprazole in patients with alcoholic peptic ulcer. Methods A total of 108 patients with alcoholic peptic ulcer admitted to hospital were enrolled in this study. According to the random number table, 54 patients were divided into two groups. Lansoprazole group with clarithromycin, amoxicillin and lansoprazole treatment, omeprazole group with clarithromycin, amoxicillin and omeprazole treatment. The clinical effects of two groups were compared. Results The total effective rate in the lansoprazole group was 96.30% higher than that in the omeprazole group (87.04%, P <0.05). Hp clearance rate in lansoprazole group was 90.74% higher than that in omeprazole group (77.78%, P <0.05). The incidence of adverse reactions in lansoprazole group was 3.70% lower than that in omeprazole group (12.96%, P <0.05). Conclusion Lansoprazole treatment of alcoholic peptic ulcer effect is significant, Hp clearance rate was higher, clinical symptoms improved significantly, and the safety is high, it is worth clinical application and promotion.