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目的 探讨细胞凋亡抑制基因ｂｃｌ－ ２ 和凋亡促进基因ｂａｘ 在胆管癌组织中的表达。方法 应用免疫组化方法对２０ 例胆管癌（ＣＨＣ）和７例先天性胆总管囊肿（ＣＣＣ）组织中ｂｃｌ－ ２和ｂａｘ 蛋白进行检测。结果 ２０例ＣＨＣ中有１例ｂｃｌ－ ２ 蛋白表达阳性（５％ ），７例ＣＣＣ中ｂｃｌ－ ２均表达阴性。２０例ＣＨＣ中有１１ 例ｂａｘ 蛋白表达阳性（５５％ ），７例ＣＣＣ中仅１ 例表达阳性（１４．２９％ ），两组间差异有显著意义（Ｐ＜ ０．０１）。结论 ｂｃｌ－ ２ 和ｂａｘ 蛋白的改变在胆管癌发生发展过程中不起重要作用。
Objective To investigate the expression of apoptosis suppressor gene bcl-2 and apoptosis-promoting gene bax in cholangiocarcinoma. Methods Immunohistochemistry was used to detect bcl-2 and bax protein in 20 cases of cholangiocarcinoma (CHC) and 7 cases of congenital choledochal cyst (CCC). Results The expression of bcl-2 protein was positive in 1 of 20 cases of CHC (5%). Bcl-2 was negative in 7 cases of CCC. Among the 20 cases of CHC, 11 were positive for bax protein expression (55%), and only 7 cases of CCC were positive (14.29%). There was a significant difference between the two groups (P<0.01). Conclusion The changes of bcl-2 and bax proteins do not play an important role in the development of cholangiocarcinoma.