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目的 探讨急性心肌梗死 (AMI)患者纤溶活性及血小板活性的动态变化规律及其相关性 方法 选择 49例Q波型、非溶栓的AMI患者及 30例正常人作为对照组。分别于发病后 1d、2d、3d、7d及 14d抽取静脉血 ,检测组织纤溶酶原激活剂 (tPA)及其抑制剂 - 1(PAI - 1)的活性 ,并同时检测血小板GPⅡb、Ⅲa的含量。结果 AMI患者中tPA、PAI- 1活性分别较对照组明显减少和升高 (P <0 .0 5 ,P <0 .0 1) ,血小板GPⅡb、Ⅲa含量较对照组明显减少 (P <0 .0 1)。结论 tPA、PAⅠ - 1、GPⅡb、Ⅲa在AMI的诊断及治疗上有重要价值
Objective To investigate the dynamic changes of fibrinolytic activity and platelet activity in patients with acute myocardial infarction (AMI) and its correlation. Methods Forty-nine patients with Q wave, non-thrombolytic AMI and 30 healthy controls were selected as control group. Venous blood was drawn on the 1st, 2nd, 3rd, 7th and 14th day after onset to detect the activity of tissue plasminogen activator (tPA) and its inhibitor - 1 (PAI - 1) content. Results The activities of tPA and PAI-1 in AMI patients were significantly decreased and increased compared with those in control group (P <0.05, P <0.01). The contents of GPⅡb and Ⅲa in platelet in patients with AMI were significantly lower than those in control group (P <0.05). 0 1). Conclusion tPA, PA Ⅰ - 1, GP Ⅱ b, Ⅲ a have important value in the diagnosis and treatment of AMI