论文部分内容阅读
目的通过观察寒喘宁口服液对实验性哮喘豚鼠支气管肺泡灌洗液(BLAF)中γ-干扰素(IFN-γ)、白介素4(IL-4)水平的影响,探讨寒喘宁口服液对实验性哮喘豚鼠的治疗作用。方法选50只体重为250 g-300 g的雄性幼龄豚鼠,通过随机数字表法分成正常对照组、地塞米松组、哮喘模型组、中药大剂量组、中药小剂量组5组,每组各10只。造模后各组按要求罐药,测定BLAF中IFN-γ和IL-4的含量。结果哮喘模型组与正常对照组比较IFN-γ显著降低(P<0.01),IL-4显著升高(P<0.01)。与哮喘模型组比较,地塞米松组、中药大剂量组、中药小剂量组IFN-γ水平显著升高(P<0.01),IL-4显著降低(P<0.01)。结论寒喘宁口服液能升高实验性哮喘豚鼠BLAF中IFN-γ的水平和降低IL-4的水平,寒喘宁口服液可能是治疗儿童支气管哮喘的有效药物。
Objective To observe the effects of Hanchuanning Oral Liquid on the levels of IFN-γ and IL-4 in bronchoalveolar lavage fluid (BLAF) of experimental asthmatic guinea pigs, Therapeutic effects of experimental asthma in guinea pigs. Methods Fifty male guinea pigs weighing 250-300 g were randomly divided into normal control group, dexamethasone group, asthma model group, high-dose Chinese medicine group and traditional Chinese medicine low-dose group. Each group Each 10. After modeling, each group required cans of medicine to determine the content of IFN-γ and IL-4 in BLAF. Results Compared with normal control group, the level of IFN-γ in asthmatic model group was significantly lower (P <0.01) and IL-4 was significantly higher (P <0.01). Compared with the asthma model group, the levels of IFN-γ in dexamethasone group, high-dose group and low-dose group were significantly increased (P <0.01) and IL-4 significantly decreased (P <0.01). Conclusion Hanchuanning Oral Liquid can increase the level of IFN-γ in BLAF and decrease the level of IL-4 in experimental asthmatic guinea pigs. Hanchuanning Oral Liquid may be an effective drug for the treatment of bronchial asthma in children.