作者报道,前列腺素治疗有效地保护长期应用非甾体类抗炎药(NSAIDs)引起的胃溃疡。对420例诊为骨关节炎的病人随机分配,采用前列腺素类似物 misoprostol(cytotec)200μg 每日4次为一组,100μg 每日4次为一组,并用安慰剂作配对的对照组;同时予以 NSAIDs(包括布洛芬、炎痛喜康及甲氧萘丙酸治疗3月,所有病人均在每个月作内窥镜检查。结果显示:用安慰剂的138例病人发生胃溃疡者为21.7%,用100μg misoprostol The authors report that prostaglandin therapy effectively protects against chronic gastric ulcer caused by non-steroidal anti-inflammatory drugs (NSAIDs). A total of 420 patients with osteoarthritis were randomized to receive either a 200 μg dose of the prosoprin analog 200 μg once daily in a single dose of 100 μg four times a day and placebo-paired control; meanwhile, All patients were treated with NSAIDs (including ibuprofen, piroxicam, and naproxen) for 3 months, and all patients underwent endoscopy every month. The results showed that 138 patients with placebo had gastric ulcer 21.7% with 100 μg misoprostol