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咖啡是世界上最流行的饮料之一,研究表明,患慢性肝病同时又饮用咖啡的人患肝硬化及肝癌的风险更低。随着非酒精性脂肪性肝病(Non-alcoholic Fatty Liver Disease,NAFLD)全球患病率日益增加,咖啡摄入对NAFLD的影响受到了新的关注。本文对咖啡摄入减轻NAFLD严重程度的流行病学、临床证据及其作用机制进行了综述。咖啡尤其是咖啡因之外的其它成分可以减少NAFLD的患病率及非酒精性脂肪性肝炎(Non-Alcohol Steatohepatitis,NASH)的炎症反应。咖啡对NAFLD的护肝作用与抗氧化、抗炎及抗纤维化等机制有关。目前支持这些作用的数据仍十分有限,值得进一步的研究和讨论。
Coffee is one of the most popular drinks in the world and studies show that people who have chronic liver disease and drink coffee have a lower risk of cirrhosis and liver cancer. With the global prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) increasing, the impact of coffee intake on NAFLD has received new attention. This article reviews the epidemiology, clinical evidence and mechanism of coffee intake to reduce the severity of NAFLD. Coffee, especially caffeine, can reduce the prevalence of NAFLD and the inflammatory response of non-alcoholic steatohepatitis (NASH). The protective effect of coffee on NAFLD is related to anti-oxidation, anti-inflammatory and anti-fibrosis mechanisms. The current data supporting these roles are still very limited and deserve further study and discussion.