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本文用头孢霉素Ⅱ,马桑内酯,印防已毒素和青霉素造成清醒大鼠实验性癫痫发作,研究了东亚钳蝎毒抗癫痫肽(AEP)的抗癫痫作用,比较了AEP与已知抗癫痫药在作用方式及特点上的异同。实验表明,AEP对上述4种模型癫痫发作有明显的抑制作用,在不同的模型上表现了不同的方式及性质。与苯妥英钠、卡马西平和抗癫痫灵相比,AEP作用强,用量小,毒性低;在印防已毒素模型上作用与苯妥英钠相似,在青霉素模型上作用与抗痫灵相似。
In this paper, experimental epileptic seizures were induced in awake rats by cephalosporin II, macadamia, phoxim and penicillin. The antiepileptic effects of antiseepiegic peptide (AEP) Similarities and differences of antiepileptic drugs in mode of action and characteristics. Experiments show that, AEP on the four models of seizures significantly inhibited the performance of different models in different ways and nature. Compared with phenytoin sodium, carbamazepine and anti-epileptic Ling, AEP strong role, with a small amount of low toxicity; in the printed toxin model and sodium phenytoin similar role in the penicillin model and anti-epileptic Ling similar.