自从1977年证明在中枢神经系统存在苯二氮(?)(BDZ)受体以来,就设想如同吗啡类药与纳洛酮的关系一样,必然有BDZ的拮抗药。1979年Roche制药厂研究室的研究者果然发现咪唑二氮(?)的一个衍生物具有拮抗BDZ的作用。此药最初的代号为RO15-1788,以后定名为Flumazenil(以下称FZ)由于此药具有重要的理论和实际意义,引起 Since it was demonstrated in 1977 that benzodiazepine (BDZ) receptors are present in the central nervous system, it is envisaged that there must be antagonists of BDZ, as in the case of morphine and naloxone. Researchers at the Roche Pharmaceutical Laboratory in 1979 really found that a derivative of imidazole diazepam has an antagonistic effect on BDZ. The drug was originally named RO15-1788, later named Flumazenil (hereinafter referred to as FZ) Because this medicine has important theoretical and practical significance, caused