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目的观察肝素钙对慢性肾功能不全 (CRI)的治疗作用及不良反应。方法应用肝素钙治疗 3 4例早期CRI患者并对其肾功能、脂质代谢、凝血指标及 2 4h尿蛋白排出量进行了治疗前后的观察。结果观察组治疗后与治疗前相比血肌酐、尿素、尿蛋白明显下降 ,内生肌酐清除率明显升高 ;观察组治疗前纤维蛋白原、总胆固醇 (Tch)、甘油三酯 (TG)、低密度脂蛋白 (LDL)较对照组明显增高 ;活化部分凝血活酶时间 (APTT)、高密度脂蛋白 (HDL)、载脂蛋白A(ApoA)、ApoA ApoB较对照组明显降低 ;治疗前后相比APTT、HDL、ApoA、ApoA ApoB明显升高 ,纤维蛋白原、Tch、TG、LDL明显下降 ;无明显副作用。结论肝素钙具有降低尿蛋白、纠正脂质代谢紊乱、改善血液黏度的作用 ,治疗CRI安全可靠
Objective To observe the therapeutic effect and adverse reactions of heparin calcium on chronic renal insufficiency (CRI). Methods 34 patients with early CRI were treated with heparin calcium and their renal function, lipid metabolism, coagulation index and 24 h urinary protein excretion were observed before and after treatment. Results The serum creatinine, urine urea and urine creatinine in the observation group were significantly lower than those before treatment, and the creatinine clearance rate was significantly increased in the observation group. The levels of fibrinogen, total cholesterol (Tch), triglyceride (TG) LDL was significantly higher than that of the control group; APTT, HDL, ApoA and ApoA were significantly lower than those in the control group; Compared with APTT, HDL, ApoA and ApoA ApoB, fibrinogen, Tch, TG and LDL were significantly decreased; no obvious side effects were found. Conclusion Heparin calcium has the function of reducing urinary protein, correcting lipid disorder and improving blood viscosity, and it is safe and reliable to treat CRI