恶性胸水是恶性肿瘤的常见并发症,常引起呼吸困难和胸痛。治疗多为姑息性,向胸腔内注入抗癌药物或胸膜硬化剂常能有效地预防胸水再发生。本研究比较博莱霉素与四环素联合胸腔注射与博莱霉素或四环素单独应用时对恶性胸水的治疗效果。 对象为化疗(平均8.95±8.63周)无效、经组织学或细胞学证实有大量恶性胸水患者60例,其中乳癌20例、肺癌19例、淋巴瘤4例、其它16例;平均年龄为53.55±9.10岁。胸水位于右侧39例、左侧21例;血性胸水14例、浆液纤维素性46例。随机分为3组,每组 Malignant pleural effusion is a common complication of malignant tumors and often causes breathing difficulties and chest pain. Treatment is mostly palliative. Injecting anticancer drugs or pleural sclerosing agents into the chest can often prevent pleural effusion from occurring again. This study compared the therapeutic effect of bleomycin and tetracycline combined with intrapleural injection and bleomycin or tetracycline alone on malignant pleural effusion. The subjects were chemotherapy (mean 8.95±8.63 weeks) was invalid, histologically or cytologically confirmed there were 60 cases of malignant pleural effusions, including 20 cases of breast cancer, 19 cases of lung cancer, 4 cases of lymphoma, and 16 other cases; the average age was 53.55± 9.10 years old. The pleural effusion was located in 39 cases on the right side and 21 cases on the left side; there were 14 cases of bloody pleural effusion and 46 cases of serous fibrinoidity. Randomly divided into 3 groups, each group