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已知糖尿病早期肾小球滤过率(GFR)升高,并与糖尿病肾病的发展有关[1,2]。肾小动脉血管平滑肌的收缩改变了肾血流动力学是引起GFR升高的原因之一。探索糖尿病肾血管平滑肌收缩的调控因素可为进一步阐明糖尿病发生发展机制打下良好的基础。肌球蛋白轻链激酶(MLCK)表达增加和活性
Early diabetic glomerular filtration rate (GFR) is known to be elevated and is associated with the development of diabetic nephropathy [1,2]. Renal arteriolar vascular smooth muscle contraction changes in renal hemodynamics is one of the causes of increased GFR. Exploring the regulatory factors of diabetic renal vascular smooth muscle contraction can lay a good foundation for further elucidating the mechanism of the occurrence and development of diabetes. Myosin light chain kinase (MLCK) expression increased and activity