青霉素G或苄基青霉素(I)作为第一个广泛应用的抗菌素自其发见(1928)和使用(1944)以来仍然保持着最重要的地位,然在长期应用过程中也出现了一些缺点,如易受酸水解因而口服效力不佳,出现抗青霉素的致病性菌株和对某些患者会引起过敏症。人们一向认为,青霉素的优越的医疗性能依存于 As the first widely used antibiotic, penicillin G or benzylpenicillin (I) still holds the most important position since its introduction (1928) and its use (1944). However, there have been some shortcomings in the long-term application of penicillin G or benzyl penicillin (I) Such as susceptible to acid hydrolysis and poor oral efficacy, the emergence of pathogenic strains resistant to penicillin and some patients can cause allergies. People always think that penicillin superior medical performance dependent