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为了探讨女性激素在子宫内膜腺癌和子宫内膜增生过长发病中的作用，为临床内分泌治疗提供理论依据，作者采用免疫组织化学ＳＰ法，对手术切除和诊刮的１７例子宫内膜腺癌和４０例子宫内膜增生过长标本进行ＥＲ、ＰＲ和ＰＣＮＡ含量检测，并结合组织学类型和分化程度进行分析。结果显示内膜腺癌组织中ＥＲ、ＰＲ的含量低于增生期和增生过长内膜组织（Ｐ＜０．０５），与肿瘤的组织学类型和分化有关。ＰＣＮＡ在子宫内膜腺癌中的含量显著高于非肿瘤性内膜组织（Ｐ＜０．０１），与分化程度呈负相关。与ＥＲ、ＰＲ的含量无明显相关性。结果表明ＥＲ在子宫内膜增生过长和内膜腺癌的发病中起重要作用，ＰＣＮＡ的过度表达可能与细胞的异常生长和分化有关。
In order to explore the role of female hormones in the pathogenesis of endometrial adenocarcinoma and endometrial hyperplasia, provide a theoretical basis for clinical endocrine therapy. The authors used immunohistochemical SP method in 17 cases of endometrial resection and curettage Adenocarcinoma and 40 cases of endometrial hyperplasia samples were detected ER, PR and PCNA content, combined with histological types and degree of differentiation were analyzed. The results showed that the content of ER and PR in endometrial adenocarcinoma was lower than that in proliferative and hyperplastic endometrial tissues (P <0.05), which was related to the histological type and differentiation of tumor. The content of PCNA in endometrial adenocarcinoma was significantly higher than that in non-neoplastic endometrial tissue (P <0.01), which was negatively correlated with the degree of differentiation. There was no significant correlation between ER and PR contents. The results showed that ER plays an important role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinoma. The overexpression of PCNA may be related to abnormal cell growth and differentiation.