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目的:分析致药物性肝病的药物种类、临床表现,探讨预防措施。方法:采取回顾性分析的方法,对本院2000年1月至2006年6月临床各科诊断药物性肝病的202例患者资料进行统计分析。结果:202例药物性肝病中男128例,女74例,年龄最小8岁,最大82岁,平均(46．96±16．67)岁;涉及药物37种,抗结核药物居首位占35．1%(71/202),中草药及其成药占第二位,为24．3%(49/202),抗肿瘤药居第三位,均占14．3%(29/202);临床分型:肝细胞型肝损伤40例(36．04%),淤胆型肝损伤43例(38．74%),混合型肝损伤28例(25．22%)。结论:致药物性肝病的药物品种较多,要掌握导致药物性肝病的相关危险因素,定期检查肝功能,早期发现、及时停药、早期诊断、及时治疗是预后良好的关键。
OBJECTIVE: To analyze the drug type, clinical manifestations and prevention measures of drug-induced liver disease. Methods: A retrospective analysis of the hospital from January 2000 to June 2006 clinical diagnosis of drug-induced liver disease in 202 patients with statistical data. Results: 202 cases of drug-induced liver disease in 128 males and 74 females, the youngest 8 years old, maximum 82 years old, with an average (46.96 ± 16.67) years; 37 kinds of drugs involved, anti-TB drugs in the first place accounted for 35 .1% (71/202), the second place for Chinese herbal medicine and its proprietary medicines was 24.3% (49/202), the third place for antineoplastic drugs (14.3% (29/202) There were 40 cases (36.04%) of hepatocellular liver injury, 43 cases (38.74%) of cholestatic liver injury and 28 cases (25.22%) of mixed liver injury. Conclusion: There are many drug-induced liver diseases. To master the related risk factors of drug-induced liver disease, regular examination of liver function, early detection, prompt withdrawal, early diagnosis and prompt treatment are the keys to good prognosis.