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目的:探讨高压氧(HBO)和硝酸甘油联合治疗急性心肌梗塞(AMI)的效果。方法:在兔AMI 模型上观察联合应用 HBO 和硝酸甘油、单用 HBO 及单用硝酸甘油的疗效并进行比较;以胸前多导联 ECG、心肌病理染色和血液动力学数据为观察指标。结果:HBO 与硝酸甘油联合治疗方案减轻心肌损伤、缩小梗塞面积、保护心功能的效果显著优于单纯 HBO 或硝酸甘油治疗。结论:硝酸甘油对 HBO 具有协同效应,可明显增强 HBO 对 AMI 的疗效。
Objective: To investigate the effect of combined hyperbaric oxygen (HBO) and nitroglycerin in the treatment of acute myocardial infarction (AMI). Methods: The curative effect of combined use of HBO and nitroglycerin, HBO alone and nitroglycerin alone was observed and compared in the rabbit AMI model. The multi-lead ECG, myocardial pathological staining and hemodynamic data were used as the observational indexes. Results: HBO combined with nitroglycerin could relieve myocardial injury, reduce infarct size and protect heart function significantly better than HBO alone or nitroglycerin. Conclusion: Nitroglycerin has a synergistic effect on HBO, which can significantly enhance the efficacy of HBO on AMI.