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目的:研究脑梗死与血浆同型半胱氨酸(HCY)的相关性。方法:采用化学发光免疫分析法测定120例脑梗死患者的血浆HCY、叶酸(Fol)、维生素B12(VitB12)等指标,并与60名健康对照者相比。结果:①脑梗死组的血浆HCY水平和甘油三酯(TG)明显高于对照组,而Fol及VitB12水平则低于对照组(P<0.01)。②血浆HCY水平增高组发生脑梗死的相对危险度为5.909(95%置信区间为2.74～12.74)。③与脑梗死有关的因素分别为HCY、Fol、VitB12、TG和收缩压(SBP)、舒张压(DBP)。条件Logistic回归模型检验发现HCY、TG、高密度脂蛋白(HDL)和SBP为脑梗死的独立致病因素。④脑梗死组和对照组血浆HCY水平与血Fol、VitB12水平均呈显著负相关性。结论:高同型半胱氨酸血症是脑梗死的独立致病因素。
Objective: To study the correlation between cerebral infarction and plasma homocysteine (HCY). Methods: Chemiluminescent immunoassay was used to determine the plasma HCY, follate (Fol) and vitamin B12 (VitB12) levels in 120 patients with cerebral infarction and compared with 60 healthy controls. Results: ①The levels of plasma HCY and triglyceride in cerebral infarction group were significantly higher than those in control group, while Fol and VitB12 levels were lower than those in control group (P <0.01). ② The relative risk of cerebral infarction was 5.909 (95% confidence interval was 2.74 ~ 12.74) in patients with elevated plasma HCY levels. ③ The factors related to cerebral infarction were HCY, Fol, VitB12, TG, SBP and DBP. Conditional logistic regression model test found that HCY, TG, high density lipoprotein (HDL) and SBP were independent risk factors of cerebral infarction. ④ The levels of plasma HCY in cerebral infarction group and control group were significantly negatively correlated with the levels of serum Fol and VitB12. Conclusion: Homocysteinemia is an independent risk factor for cerebral infarction.