在大骨节病(KBD)病因研究中,已经证实病区腐植酸物质能够对体外培养的软骨细胞产乍损伤作用,表现为细胞形态异常或死亡和脂质过氧化产物含量增加等,补充不同硒化合物对损伤有保护作用。同时,病人软骨样品生化指标分析和尿代谢产 In the study of the cause of KBD, it has been confirmed that the humic substances in the ward can produce chalking effects on chondrocytes cultured in vitro, showing abnormal cell morphology or death and increased content of lipid peroxidation products to supplement different selenium Compounds have a protective effect on injury. At the same time, the patient’s biochemical analysis of cartilage samples and urine metabolites