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[目的]分析双表型急性白血病临床生物学特征。[方法]对22例BAL患者的骨髓标本分别进行光镜细胞形态学及相关细胞化学染色观察以确定其FAB分型,应用流式细胞仪做免疫分型检测一系列相关单抗,采用兼顾AML和ALL的治疗方案。[结果]BAL的FAB分型以AML-M1/M2,ALL为主;免疫分型以B系、髓系混合表达多见,CD34在BAL中呈高表达并且是对患者预后影响力最大的因素(P=0.03);患者对治疗反应差、缓解率低。[结论]BAL属特殊类型白血病,有独特的临床生物学特征,对化疗方案不敏感,预后较差。
[Objective] To analyze the clinical biological characteristics of dual-phenotype acute leukemia. [Methods] Bone marrow specimens of 22 BAL patients were observed by light microscopy and related cytochemical staining to determine the FAB typing. A series of related monoclonal antibodies were detected by flow cytometry immunophenotyping. And ALL treatment options. [Results] The FAB typing of BAL was mainly AML-M1 / M2 and ALL. The immunophenotyping was more common in B lineage and myeloid lineage, and CD34 was highly expressed in BAL and was the most influential factor in the prognosis of patients (P = 0.03). Patients had poor response to treatment and low response rate. [Conclusion] BAL is a special type of leukemia, which has unique clinical biological characteristics and is insensitive to chemotherapy regimens with poor prognosis.