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目的探讨丙种球蛋白治疗小儿病毒性脑炎的临床疗效。方法选取2015年8月—2017年2月小儿病毒性脑炎患儿84例。随机将患儿分为对照组与丙种球蛋白组,各42例。对照组患者予以常规治疗,丙种球蛋白组在对照组基础上给予丙种球蛋白治疗,连续治疗3~7 d。比较两组患儿临床疗效、干预前后患儿C反应蛋白(CRP)水平与脑脊液、发热缓解时间、意识转清时间、停止抽搐时间、出院时间及不良反应发生情况。结果丙种球蛋白组治疗总有效率为80.95%(34/42),高于对照组的95.24%(40/42)(P<0.05)。干预前两组患儿CRP水平、脑脊液比较,差异无统计学意义(P>0.05);干预后丙种球蛋白组CRP水平、脑脊液低于对照组(P<0.05)。丙种球蛋白组发热缓解时间、意识转清时间、停止抽搐时间、出院时间短于对照组(P<0.05)。两组均未出现严重不良反应。结论丙种球蛋白治疗小儿病毒性脑炎的临床疗效确切,可有效缓解患儿病情,改善临床症状,改善脑脊液和CRP,利于患儿预后。
Objective To investigate the clinical efficacy of gamma globulin in the treatment of viral encephalitis in children. Methods From August 2015 to February 2017, 84 children with viral encephalitis were selected. Children were randomly divided into control group and gamma globulin group, 42 cases each. Patients in the control group were treated routinely. Gamma globulin group was administered gamma globulin on the basis of the control group, and was continuously treated for 3-7 days. The clinical curative effect, the level of C-reactive protein (CRP) in children with cerebrospinal fluid, fever remission time, consciousness clearing time, stopping seizure time, discharge time and adverse reactions were compared between the two groups. Results The total effective rate of gamma globulin treatment was 80.95% (34/42), which was higher than 95.24% (40/42) in control group (P <0.05). There was no significant difference in CRP level and cerebrospinal fluid between two groups before intervention (P> 0.05). CRP level in cerebrospinal fluid and cerebrospinal fluid were lower in intervention group than those in control group (P <0.05). Gallbladder fever relief time, consciousness to clear the time, stop the twitch time, discharge time is shorter than the control group (P <0.05). No serious adverse reactions occurred in either group. Conclusion Gamma globulin is effective in treating children with viral encephalitis, which can effectively alleviate the condition of children, improve clinical symptoms, improve cerebrospinal fluid (CSF) and CRP, which will benefit the prognosis of children.