Study on antisperm autoimmunity in experimental cryptorchid rats

来源 :Asian Journal of Andrology | 被引量 : 0次 | 上传用户:ggf9988998
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Objective: To investigate the occurrence of antisperm autoimmu-nity in experimental cryptorchid rats and its effect on testis. Methods: 24 male SD rats (22 day old) were divided randomly into the unilateral cryptorchid and the sham-operated groups of 12 animals each. ELISA was used to detect the serum AsAb and immunohistochemical (SABC) method to detect IgG in the testis. Results: The serum AsAb positive rates of the cryptorchid group and the sham-operated group were 41.7 % and zero, respectively, the difference being significant (P<0.05). The spermatogenisis scores of the cryptorchid and the contralateral testes were significantly lower than those of the corresponding testis in the sham-operated group. The deposition of IgG was negatively related to the spermatogenesis in the cryptorchid (r=-0.860, P<0.001) and the contralateral testes (r=-0.693, P<0.02). Conclusion: Antisperm autoimmunity is observed in experimental cryptorchid rats, which may be one reason of bilateral testicular damage. Objective: To investigate the occurrence of antisperm autoimmu-nity in experimental cryptorchid rats and its effect on testis. Methods: 24 male SD rats (22 day old) were divided randomly into the unilateral cryptorchid and the sham-operated groups of 12 The serum AsA positive rates of the cryptorchid group and the sham-operated group were 41.7% and zero, respectively, the animals The differences were significant (P <0.05). The spermatogenisis scores of the cryptorchid and the contralateral testes were significantly lower than those of the corresponding testis in the sham-operated group. The deposition of IgG was negatively related to the spermatogenesis in the cryptorchid (r = -0.860, P <0.001) and the contralateral testes (r = -0.693, P <0.02). Conclusion: Antisperm autoimmunity is observed in experimental cryptorchid rats, which may be one reason of bilateral tes ticular damage.
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