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目的 :探讨妊娠高血压综合征 (PIHS)患者血浆内皮细胞因子和胰岛素样生长因子水平与新生儿出生体重 (NBW )的关系。方法 :用放射免疫法测定 33例PIHS患者和 32例正常妊娠者的血浆内皮素 1(ET 1)、胰岛素样生长因子 (IGF 1)水平 ,收集的临床资料输入计算机分析。结果 :PIHS患者NBW与正常妊娠组差异有显著性 (P <0 .0 5 ) ,重度妊高征患者的血浆ET 1水平显著高于正常妊娠和轻度妊高征组 (P <0 .0 5、P <0 .0 1) ,并与NBW呈明显的负相关 (r =- 0 .2 86 ,P <0 .0 5 ) ;重度妊高征组的IGF 1水平显著低于正常妊娠组。NBW随PIHS患者严重程度的加剧而降低 ,各组间差异有显著性 (P =0 .0 2 )。结论 :ET 1和IGF 1在PIHS的发病中可能起重要的作用 ,并与胎儿的发育及NBW有明显的相关性
Objective: To investigate the relationship between plasma endothelin and insulin-like growth factor levels and neonatal birth weight (NBW) in patients with pregnancy-induced hypertension (PIHS). Methods: Plasma ET - 1 and IGF - 1 levels were measured by radioimmunoassay in 33 PIHS patients and 32 normal pregnant women. The clinical data were collected and analyzed by computer. Results: There was significant difference between NBW and normal pregnancy in PIHS patients (P <0.05). The plasma levels of ET 1 in patients with severe PIH were significantly higher than those in normal pregnancy and mild PIH (P <0. 0 5, P <0.01), and negatively correlated with NBW (r = - 0.266, P <0.05). IGF 1 level in severe PIH group was significantly lower than that in normal pregnancy group . NBW decreased with the severity of PIHS patients, the difference was significant among the groups (P = 0. 02). Conclusion: ET 1 and IGF 1 may play an important role in the pathogenesis of PIHS and have obvious correlation with fetal development and NBW