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目的:比较CF化疗方案(卡铂联合5-氟脲嘧啶)对口腔鳞癌患者行时辰动脉灌注新辅助化疗与常规动脉灌注新辅助化疗的疗效和毒副作用。方法:2001.9.~2005.6.收治的以卡铂联合5-Fu行动脉灌注新辅助化疗的T2~T4口腔鳞癌患者126例,随机分为时辰动脉灌注化疗组(治疗组)69例和常规动脉灌注化疗组(对照组)57例,比较化疗2个疗程后两组的疗效和毒副作用。结果:治疗组和对照组的有效率分别为75.36%、68.42%(P>0.05),两组疗效无显著性差异;治疗组和对照组的毒副作用发生率分别为34.10%、49.12%(P<0.05),治疗组的毒副作用发生率显著低于对照组。结论:卡铂联合5-Fu对口腔鳞癌患者行时辰动脉灌注化疗和常规动脉灌注化疗经2个疗程治疗后其疗效未见显著性差异,但时辰动脉灌注化疗大大降低了毒副作用的发生率,且方法简单易行。
OBJECTIVE: To compare the efficacy and side effects of CF chemotherapy (carboplatin combined with 5-fluorouracil) in patients with oral squamous cell carcinoma undergoing neoadjuvant chemotherapy and intra-arterial neoadjuvant chemotherapy. Methods: From September 2001 to June 2005, 126 patients with T2 ~ T4 oral squamous cell carcinoma treated with carboplatin combined with 5-Fu intra-arterial infusion were randomly divided into two groups: 69 patients in the chemoembolization group (n = 69) and normal artery In the chemotherapy group (control group) 57 cases, the curative effect and side effect of the two groups after chemotherapy were compared. Results: The effective rates of the treatment group and the control group were 75.36% and 68.42%, respectively (P> 0.05), and there was no significant difference between the two groups. The incidences of toxic and side effects in the treatment group and the control group were 34.10% and 49.12%, respectively <0.05), the incidence of toxic side effects in the treatment group was significantly lower than that in the control group. Conclusions: There is no significant difference in the curative effect between carboplatin combined with 5-Fu and chemoradiotherapy in patients with oral squamous cell carcinoma undergoing chemoradiotherapy and routine arterial infusion chemotherapy after two courses of chemotherapy. However, the time-course arterial infusion chemotherapy significantly reduced the incidence of toxic and side effects , And the method is simple and easy.