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目的探讨广州市医药市场上销售的药用明胶硬胶囊壳中重金属元素镉的含量,为建立药用明胶硬胶囊壳中重金属元素镉的检测标准方法和限量控制标准提供科学依据。方法利用石墨炉原子吸收分光光度法检测药用明胶硬胶囊壳中镉的含量。结果该方法线性范围为0～5μg/L,回归方程为A=0.01262C+0.02238(r=0.9978,n=3),回收率为99.3%～100.1%,仪器检出限为0.03μg/L。所测定的硬胶囊壳中镉含量在0.13～0.42μg/g浓度范围内。结论该方法测定药用明胶硬胶囊壳中的镉含量具有前处理简便、回收率高、结果准确、精密度好的特点,适用于测定药用明胶硬胶囊壳中镉的含量。
Objective To explore the contents of heavy metal elements cadmium in medicinal gelatin hard capsules sold in Guangzhou medical market and provide scientific basis for establishing the standard and limited control standard of heavy metal cadmium in hard gelatin capsules. Methods The content of cadmium in the shell of medicinal gelatin hard capsules was determined by graphite furnace atomic absorption spectrometry. Results The linear range of this method was 0-5 μg / L. The regression equation was A = 0.01262C + 0.02238 (r = 0.9978, n = 3). The recovery was 99.3% -100.1%. The detection limit was 0.03 μg / L. The measured content of hard capsule shell cadmium in the range of 0.13 ~ 0.42μg / g concentration. Conclusion The method for determination of cadmium in medicinal gelatin hard capsule shell has the advantages of simple pretreatment, high recovery rate, accurate result and good precision, and is suitable for determining the content of cadmium in the hard gelatin capsule shell.