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目的探讨血浆EBV DNA检测对鼻咽癌的诊断作用。方法将2006年12月至2007年3月在我科就诊、病理确诊的65例鼻咽癌作为治疗前组,经我院放疗科治疗后,分别于放疗结束后3、5、8个月来我科系统复查的病人作为治疗后组,将同期行健康体检的29例作为对照组,共3组。采用荧光定量PCR方法对3组的空腹血浆EBV DNA进行检测。结果3组间血浆EBV DNA阳性率比较有统计学意义(P<0.05);治疗后组的阳性病例全部有鼻咽癌复发,阴性病例没有复发;有、无淋巴结转移组间阳性率比较差异有统计学意义(P=0.00)。结论血浆EBV DNA是鼻咽癌诊断的重要分子标记,其阳性的病例有较高淋巴结侵袭发生率。
Objective To investigate the diagnostic value of plasma EBV DNA in nasopharyngeal carcinoma. Methods 65 cases of nasopharyngeal carcinoma diagnosed in our department from December 2006 to March 2007 were treated as the pre-treatment group. After radiotherapy treatment in our hospital, they were treated with 3,5 and 8 months after the end of radiotherapy Our department system review of patients as a treatment group, the same period, 29 cases of healthy physical examination as a control group, a total of 3 groups. Three groups of fasting plasma EBV DNA were detected by fluorescence quantitative PCR. Results The positive rates of plasma EBV DNA in the three groups were statistically significant (P <0.05). After treatment, all the positive cases had recurrence of nasopharyngeal carcinoma and no recurrence in the negative cases. There was a significant difference between the positive rates of EBV DNA in the group without lymph node metastasis Statistical significance (P = 0.00). Conclusion The plasma EBV DNA is an important molecular marker for the diagnosis of nasopharyngeal carcinoma, and the positive cases have a higher incidence of lymph node invasion.