目前需要研制一种抗病毒制剂,使其能导向肝脏以增强抗病毒作用并减少肝外毒性。已发现2’,3’-双羟鸟苷(ddG)在体内外具有选择性抑制HBV复制的作用,而抗病毒核苷的磷脂类前体药物能导向肝脏且可保留其重要的抗病毒作用。本文作者合成了一系列磷脂酰双羟鸟苷以导向肝脏观察其抗病毒活性。 Currently, there is a need to develop an anti-viral agent that can be directed to the liver to enhance antiviral activity and reduce extrahepatic toxicity. It has been found that 2 ’, 3’-bihydroguanosine (ddG) has a selective inhibitory effect on HBV replication both in vitro and in vivo, while phospholipid prodrugs of antiviral nucleosides can lead to the liver and retain their important antiviral effects . The authors synthesized a series of phosphatidylglycine to target the liver to observe its antiviral activity.