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目的：探讨类风湿性关节炎（ＲＡ）患者的细胞免疫状态及其在发病机理中的作用。方法：检测４３例ＲＡ患者外周血ｓＩＬ２Ｒ、Ｔ细胞亚群及淋巴细胞转化率。结果：ＲＡ患者ｓＩＬ２Ｒ、淋巴细胞转化率明显高于正常人，经治疗好转后，有明显降低。活动期ＣＤ＋４细胞增加，ＣＤ＋８明显降低，ＣＤ＋４／ＣＤ＋８比值升高；治疗好转后，ＣＤ＋４降低不明显，ＣＤ＋８明显回升，ＣＤ＋４／ＣＤ＋８比值下降。结论：ＲＡ患者体内淋巴细胞处于高激活状态，其细胞免疫功能紊乱与ＲＡ发病机理有关。
Objective: To investigate the cellular immune status in rheumatoid arthritis (RA) patients and its role in pathogenesis. Methods: 43 cases of RA patients with peripheral blood sIL 2R, T cell subsets and lymphocyte transformation rate. Results: The sIL2R and lymphocyte transformation rates of RA patients were significantly higher than those of normal subjects. After treatment, the levels of sIL2R were significantly decreased. The number of CD + 4 cells increased, the percentage of CD + 8 decreased significantly and the ratio of CD + 4 / CD + 8 increased. After treatment, the decrease of CD + 4 was not obvious. Conclusion: Lymphocytes in RA patients are highly activated and their cellular immune dysfunction is related to the pathogenesis of RA.