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目的探讨无创正压通气(NIPPV)治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭的临床疗效。方法收集46例慢性阻塞性肺疾病合并呼吸衰竭患者资料,将患者随机分为对照组和观察组,各23例。对照组患者给予低流量氧疗、支气管舒张药物、抗感染等常规治疗,观察组患者在对照组常规治疗基础上行NIPPV治疗。比较两组患者的肺功能指标、动脉血气指标、气管插管率、病死率。结果治疗前,两组患者的肺功能比较差异无统计学意义(P>0.05);治疗后,两组患者肺功能较治疗前均明显改善,观察组明显优于对照组;观察组患者的气管插管率及病死率均明显低于对照组;观察组患者有效率为82.6%,明显优于对照组的65.2%,差异均有统计学意义(均P<0.05)。结论 NIPPV能明显改善COPD合并呼吸衰竭患者的呼吸情况及预后。
Objective To investigate the clinical efficacy of noninvasive positive pressure ventilation (NIPPV) in the treatment of chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods The data of 46 patients with chronic obstructive pulmonary disease and respiratory failure were collected. The patients were randomly divided into control group and observation group, with 23 cases in each group. Patients in the control group were given conventional therapy of low-flow oxygen therapy, bronchodilator drugs and anti-infection. Patients in the observation group were treated with NIPPV on the basis of routine treatment in the control group. The pulmonary function, arterial blood gas index, endotracheal intubation rate and mortality were compared between the two groups. Results Before treatment, there was no significant difference in lung function between the two groups (P> 0.05). After treatment, the lung function of both groups was significantly improved compared with that before treatment, and the observation group was significantly better than the control group. The trachea Intubation rate and mortality were significantly lower than the control group; observation group, the effective rate was 82.6%, significantly better than the control group, 65.2%, the differences were statistically significant (P <0.05). Conclusion NIPPV can significantly improve the respiratory status and prognosis of COPD patients with respiratory failure.