运用体外培养技术 ,以加高脂血清和调肝导浊中药等不同培养基分组培养大鼠主动脉平滑肌细胞 (SMC) ,用免疫组化等方法进行指标检测。结果 :调肝导浊中药可明显抑制高脂血清培养下SMC的增殖 ,其细胞增殖核抗原 (PCNA)阳性率低于造模组 ,并可降低胞内Ca2 + 含量。提示调肝导浊中药可对SMC增殖起到良好调控作用 ,从而阻止AS发生发展 Using in vitro culture techniques, rat aortic smooth muscle cells (SMC) were cultured in groups of different media such as hyperlipidemia serum and TCM herb, and immunohistochemical methods were used for index detection. RESULTS: Liver-regulating and Turbidity-removing Chinese herbs can significantly inhibit the proliferation of SMC under hyperlipidemic serum culture. The positive rate of cell proliferation nuclear antigen (PCNA) is lower than that of the model-building group, and the intracellular Ca2+ content can be reduced. It is suggested that TCM herb can regulate the proliferation of SMC and prevent the development of AS.