论文部分内容阅读
过去曾经多次报道,卵泡液和精液能促进脑垂体促性腺激素分泌,但对其中活性物质的化学结构尚未了解。美国李卓浩等报道,从人卵泡液中分离到一个14肽,即人卵泡促性腺激素释放肽(hF-GRP)。在离体条件下,hF-GRP 具有促进垂体促性腺激素分泌的活性。用小鼠垂体培养法测定,其促进卵泡刺激素(FSH)或黄体生成素(LH)释放的 ED_(50)值分别为每管2.0μg/ml(1.2nmol/L)和2.6μg/ml(1.6nmol/L),活性比下丘脑黄体生成素释放激素(LHRH)低。初步资料表明,hF-GRP 在大鼠完整垂体培养系统及垂体
It has been repeatedly reported in the past that follicular fluid and seminal fluid can promote the secretion of gonadotropin in the pituitary gland, but the chemical structure of the active substances therein is not yet known. The United States Li Zhuohao and other reports, from human follicular fluid isolated a 14 peptide, human follicular gonadotropin-releasing peptide (hF-GRP). In vitro, hF-GRP has pituitary gonadotropin-stimulating activity. The ED 50 values of follicle stimulating hormone (FSH) or luteinizing hormone (LH) released by mouse pituitary culture were 2.0μg / ml (1.2nmol / L) and 2.6μg / ml 1.6nmol / L), activity than the hypothalamic luteinizing hormone releasing hormone (LHRH) is low. Preliminary data indicate that hF-GRP in the rat pituitary culture system and pituitary