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采用超临界辅助雾化法制备喜树碱聚乳酸亚微球用于静脉给药。用X-射线衍射和差示扫描量热分析了药物在载体中的分散状态及相互作用,并考察了制品的粒径分布、表面形态、载药量、包封率和体外释放特性。结果表明,制品外形较圆整,平均粒径为(0.61±0.15)m,载药量为7.53%,包封率为82.8%,12 h累积释放率约25%,7 d累积释放率约60%。
Preparation of camptothecin polylactic acid submicrospheres for intravenous administration by supercritical assisted atomization. X-ray diffraction and differential scanning calorimetry were used to analyze the dispersion status and interaction of the drug in the carrier. The particle size distribution, surface morphology, drug loading, entrapment efficiency and in vitro release characteristics of the product were investigated. The results showed that the product has a round shape, an average particle diameter of (0.61 ± 0.15) m, a drug loading of 7.53%, an entrapment efficiency of 82.8%, a cumulative release rate of 12% at about 25% and a cumulative release rate of about 60% %.