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BACKGROUND AND OBJECTIVE:To determine whether subconjunctival placement of amniotic membrane improves filtration results in patients with glaucoma at high risk for surgical failure.PATIENTS AND METHODS:Retrospective re view of 17 eyes of 15 patients who had amniotic membrane applied during glaucoma surgery with or without mitomycin C or 5-fluorouracil.RESULTS:Mean intraocular pressure decreased from 27.0± 9.1 mmHg preoperatively to 18.1± 11.0 mmHg postoperatively with a mean follow-up of 179 days.Complications included self-limited conjunctival wound dehiscence(n=5) ,uveitis recurrence(n=2) ,and cataract progression(n=1) .CONCLUSIONS:The results suggest that subconjunctival placement of amniotic membrane may improve filtration outcome in high risk eyes.It will be of interest to determine whether the anti-inflammatory,anti-angiogenic,and antifibrotic properties of amniotic membrane placed subconjunctivally and under the scleral flap will improve filtration surgery outcome by a prospective,randomized study.
BACKGROUND AND OBJECTIVE: To determine whether subconjunctival placement of amniotic membrane improves filtration results in patients with glaucoma at high risk for surgical failure. PATIENTS AND METHODS: Retrospective re view of 17 eyes of 15 patients who had amniotic membrane applied during glaucoma surgery with or without mitomycin C or 5-fluorouracil.RESULTS: Mean intraocular pressure decreased from 27.0 ± 9.1 mmHg preoperatively to 18.1 ± 11.0 mmHg postoperatively with a mean follow-up of 179 days .Complications included self-limited conjunctival wound dehiscence (n = 5), uveitis recurrence (n = 2), and cataract progression (n = 1). CONCLUSIONS: The results suggest that subconjunctival placement of amniotic membrane may improve filtration outcome in high risk eyes. I will be of interest to determine whether the anti-inflammatory, anti -angiogenic, and antifibrotic properties of amniotic membrane placed subconjunctivally and under the scleral flap will improve filtration surgery outcome by a prospec tive, randomized study.