用光镜和电镜观察26例流行性出血热各期患者真皮肥大细胞的变化发现,有两种类型脱粒的肥大细胞,即溶解性和非溶解脱粒细胞。二者在本病病程不同阶段有一定变化规律。早期,肥大细胞主呈溶解性脱粒变化,细胞解体,丧失。随着疾病的进展,溶解性脱粒减少,而非溶解性脱粒增多,其细胞内颗粒电子密度明显降低。两种类型的脱粒肥大细胞反映了两种脱粒形式和不同的免疫过程。本文对其在发病机制中的意义进行了讨论。 Observing the changes of dermal mast cells in 26 patients with epidemic hemorrhagic fever with light microscope and electron microscope, we found that there are two types of threshing mast cells, namely lytic and non-lytic degranulation cells. Both in the disease at different stages of a certain pattern of change. Early, main mast cells were dissolved thrombolysis changes, cell disintegration, loss. As disease progresses, soluble threshing decreases, whereas non-lytic threshes increase, with a noticeable decrease in the electron density of intracellular particles. Both types of threshing mast cells reflect two forms of threshing and different immune processes. This article discusses its significance in the pathogenesis.