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本文报告了用国产吡喹酮治疗22例胸内包虫病的临床和实验结果,旨在探讨该药对胸内包虫病的疗效问题,寻求非手术治疗的途径。实验部分采用对手术摘除的包虫标本进行分析检查的方法:一方面分别观察服药组和对照组(未服药)的原头蚴死亡率,并用这些原头蚴接种子对包虫易感的动物小白鼠腹腔内,观察继发囊肿的生长率,以此评定药物对原头蚴的作用;另一方面借助光学及电子显微镜,观察生发层的形态和改变,作为评定药效的参考指标。结果表明。吡喹酮具有杀伤包虫囊肿内原头蚴的作用。为此考虑,吡喹酮作为术前用药,可能对防止原头蚴手术野的污染而继发囊肿有所裨益。
This article reports the clinical and experimental results of 22 cases of intrathoracic echinococcosis treated with domestic praziquantel in order to explore the efficacy of the drug on intrathoracic hydatid disease and to seek ways of non-surgical treatment. In the experimental part, the echinococcosis specimens removed by surgery were analyzed and examined. On the one hand, the mortality of protoscoesiae of the drug-treated group and the control group (non-medication) was observed respectively, and these animals were susceptible to hydatid The mice were intraperitoneally observed the growth rate of secondary cysts to assess the effect of drugs on the original cercariae; the other hand, by means of optical and electron microscopy to observe the morphology and changes of the germinal layer as a reference to assess efficacy. The results show. Praziquantel has the effect of killing the original echinococcosis in hydatid cysts. For this reason, praziquantel as a preoperative medication, may be to prevent the original cercaria surgical field pollution secondary cysts have benefits.