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近年来,在化学药物发展的基础上对旋毛虫的实验治疗开展了研究,而缺囊壁的伪旋毛虫对药物的反应,可能与旋毛虫不同。本文比较了8种不同化学结构的化合物,对伪旋毛虫肌内感染的3个时期,即肌侵入期(感染后30天,简称肌Ⅰ期)、早期肌期(感染后40天,简称肌Ⅱ期)和晚肌期(感染后48及57天,简称肌Ⅲ期)的作用。用300±50条GARKAVI株伪旋毛虫幼虫感染体重为30～35g的CRI-1瑞士小鼠,然后以单剂和多剂口服药予以治疗,多剂的剂量为每天三次分服,隔4小时给药一次,
In recent years, on the basis of the development of chemical drugs, the experimental treatment of Trichinella has been studied, while the pseudocystis pseudocerasus may respond differently to the drug than the Trichinella spiralis. In this paper, eight compounds with different chemical structures were compared. Three stages of intramuscular infection of pseudotuberculosis, namely muscle invasion (30 days after infection, abbreviated as muscle Ⅰ), early muscle (40 days after infection, Ⅱ) and late muscle (48 and 57 days after infection, referred to as muscle Ⅲ) role. CRI-1 Swiss mice weighing 30-35 g were infected with 300 ± 50 Garkavi strains of pseudotubercular larvae and then treated with single and multi-dose oral doses of multiple doses three times a day over 4 hours Once,