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Novel pyrido[2,3-d]pyrimidine derivatives were synthesized through a one-pot three-component approach using HAp-encapsulated-γ-Fe_2O_3[γ-Fe_2O_3@HAp-SO_3H]catalyzed condensation of 6-arnino-2-(methylthio or ethylthio)pyrimidin-4(3H)-one,Meldrum’s acid and aryl aldehydes at 60 ℃ and under solvent-free conditions.In this protocol the use of nanocatalyst provided a green,useful and rapid method to generate the products in short reaction times and excellent yields(88%-94%).
Novel pyrido [2,3-d] pyrimidine derivatives were synthesized through a one-pot three-component approach using HAp-encapsulated -γ-Fe_2O_3 [γ-Fe_2O_3 @ HAp-SO_3H] catalyzed condensation of 6-arnino-2- or ethylthio) pyrimidin-4 (3H) -one, Meldrum’s acid and aryl aldehydes at 60 ° C under solvent-free conditions. This protocol the use of nanocatalyst provided a green, useful and rapid method to generate the products in short reaction times and excellent yields (88% -94%).