论文部分内容阅读
目的:探讨小细胞类乳腺癌细针穿刺的细胞形态学特点及鉴别诊断。方法:观察33例小细胞类乳腺癌细针穿刺细胞学涂片与93例乳腺纤维腺瘤和76例乳腺增生症并进行对照分析。结果:小细胞类乳腺癌中,细胞排列紊乱、松散,以散在或小细胞群为主,易见腺腔样、腺管样、炮竹式、栅栏状、单列纵队样排列,圆形核细胞占绝大多数,核质比明显减小,散在细胞易见、圆形核占多数、胞质完整,未见肌上皮细胞的相对病例数,均明显高于乳腺纤维腺瘤、乳腺增生症的相对病例数,差异均有统计学意义(P<0.05);细胞量中等以上的相对病例数,明显高于乳腺增生症,差异有统计学意义(P<0.05);纤维间质及其与乳腺上皮细胞混杂的相对病例数,明显低于乳腺纤维腺瘤,差异均有统计学意义(P<0.05)。结论:小细胞类乳腺癌具有不同于乳腺纤维腺瘤和乳腺增生症的细针穿刺细胞形态学特点,与乳腺纤维腺瘤、乳腺增生症可以鉴别。
Objective: To investigate the morphological features and differential diagnosis of fine-needle aspiration of small cell breast cancer. Methods: Thirty-three cases of small cell breast cancer were observed by needle aspiration cytology and 93 cases of breast fibroadenoma and 76 cases of hyperplasia of breast. Results: Small cell breast cancer cells arranged disorder, loose, mainly scattered or small cell population, easy to see the gland cavity-like, gland-like, gun bamboo, palisading, single column arrangement, round nucleated cells Accounting for the vast majority of nuclear and cytoplasm ratio was significantly reduced, scattered in cells is easy to see, the majority of round nuclei, cytoplasm integrity, no cases of myometrial epithelial cells were significantly higher than those of breast fibroadenoma, hyperplasia of mammary glands (P <0.05). The relative number of cases with medium cell density was significantly higher than that of hyperplasia of mammary glands (P <0.05). The interstitial fibrosis and its relationship with breast The relative number of epithelial cells mixed was significantly lower than that of breast fibroadenoma, the differences were statistically significant (P <0.05). Conclusion: Small cell breast cancer has the morphological characteristics of fine needle aspiration cells different from those of breast fibroadenoma and breast hyperplasia, which can be distinguished from those of breast fibroadenoma and mammary gland hyperplasia.