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目的观察应用皮肤原位再生复原技术(MEBT/MEBO)治疗带状疱疹的临床疗效。方法将100例带状疱疹患者随机分为对照组(50例)和治疗组(50例),两组患者均采用干扰素α-2β10 ug肌注,每日1次,连续3 d;口服伐昔洛韦0.3 g,每日2次;吲哚美辛肠溶片25mg,每日3次。治疗组:局部创面应用皮肤原位再生复原技术治疗,每日换药6次;对照组:局部创面外用喷昔洛韦乳膏治疗,每天换药3次,若创面继发感染,则加用夫西地酸乳膏。分别于治疗当日及治疗7 d、4 d、21 d、28 d记录皮损变化情况。结果治疗组治愈率以及后遗神经疼痛(pHN)发生率均明显低于对照组(P<0.01,P<0.01)。结论皮肤原位再生复原技术在缓解带状疱疹疼痛,促进创面愈合,缩短病程,减少后遗神经痛发生率,减轻瘢痕形成等方面作用显著。
Objective To observe the clinical efficacy of skin regeneration in situ (MEBT / MEBO) in the treatment of shingles. Methods 100 cases of shingles were randomly divided into control group (50 cases) and treatment group (50 cases). Both groups received interferon α-2β10 ug intramuscularly once a day for 3 consecutive days. Cyloxicara 0.3 g, 2 times a day; indometacin enteric-coated tablets 25mg, 3 times a day. In the treatment group, the wounds were treated with skin regeneration in situ and the dressing was changed 6 times a day. In the control group, topical wounds were treated with penciclovir cream three times a day. If the wounds were secondary to infection, Fusidic acid cream. The changes of the lesions were recorded on the treatment day and on the 7th, 4th, 21st and 28th day respectively. Results The cure rate and the incidence of posterior neuralgia (pHN) in the treatment group were significantly lower than those in the control group (P <0.01, P <0.01). Conclusion The in situ regenerative skin rejuvenation plays a significant role in relieving herpes zoster pain, promoting wound healing, shortening the course of disease, reducing the incidence of postherpetic neuralgia, and reducing the formation of scar.