肺表面洁性物质的定义没有统一意见,由于其分离与精制的方法因各研究人员而异,目前尚无天然或人工确定的肺表面活性物质。一般认为:肺表面活性物质系由Ⅱ型肺泡上皮产生,贮存于细胞的板层体中,然后分泌入肺泡腔内,在肺泡液—气界面上吸附、扩散而形成—单层膜,借助其降低表面张力的作用而防止呼气终末期时发生肺泡萎陷。1959年Avery与Mead报道:新生儿呼吸 There is no unanimous opinion on the definition of pulmonary surfactant, which is different from researcher to individual because of its separation and purification methods. There are currently no natural or artificially established pulmonary surfactants. It is generally believed that the pulmonary surfactant is produced by type II alveolar epithelium and stored in the lamellar body of the cell and then secreted into the alveolar space to adsorb and diffuse on the alveolar liquid-air interface to form a monolayer Reduce the role of surface tension to prevent alveolar collapse during end-expiration. 1959 Avery and Mead report: Newborn breathing