应用血管内皮细胞平铺技术、SEM及三级切片技术,动态观察了自发性高血压大鼠主动脉内皮细胞在不同血压下的形态改变。用伊文思蓝活体染色、辣根过氧化酶反应等方法观察了不同血压下动脉内膜通透性变化。实验结果表明,高血压因素能直接损伤动脉内皮细胞,导致动脉内膜通透性增强。研究认为高血压是引起动脉内皮细胞损伤的重要因素之一,内皮细胞的损伤是动脉粥样硬化发生的起点。 Application of vascular endothelial cell tiling technology, SEM and three slice technology, dynamic observation of spontaneous hypertensive rat aortic endothelial cells under different blood pressure changes in morphology. Evans Blue staining and horseradish peroxidase reaction were used to observe the change of arterial intima permeability under different blood pressure. Experimental results show that hypertension can directly damage arterial endothelial cells, leading to increased arterial intima permeability. Studies suggest that hypertension is one of the important factors that cause endothelial cell injury in the arteries. The damage of endothelial cells is the starting point of atherosclerosis.