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中枢神经系统(centernervous system,CNS)损伤后的修复与再生问题一直困扰医学界,主要是普遍认为CNS损伤后无法再生,导致神经功能难以恢复。1992年Reynolds和Weiss等从成年小鼠纹状体分离出一组特殊的细胞群,这些细胞在体外表现出不断分裂增殖、自我更新的能力和多向分化潜能,据此第1次提出了神经干细胞(neural stem cells,NSCs)的概念,推翻了“神经细胞不能再生”的传统观点。1997年Mckay将NSCs的概念总结为:具有分化为神经元、是形胶质细胞及少突
The repair and regeneration of the central nervous system (CNS) after injury has plagued the medical community. It is generally believed that CNS can not regenerate after injury, resulting in difficulty in recovering the nerve function. In 1992, Reynolds and Weiss isolated from the adult mouse striatum a special group of cells, these cells in vitro continued to demonstrate the ability of dividing and proliferating, self-renewal and multi-directional differentiation, the first proposed neural The concept of neural stem cells (NSCs) overturns the traditional notion that “nerve cells can not regenerate.” In 1997 Mckay summarized the concept of NSCs as having differentiated neurons, astrocytes and oligodendrocytes