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目的 探讨苯妥英钠 (PHT)治疗癫时的血清浓度 (Cp)、脑脊液浓度 (Cc)、唾液中浓度 (Cs)、血清游离浓度 (FCp)的关系。方法 用免疫荧光偏振法检测 6 2例单服PHT的癫患者以上 4种PHT浓度。结果 原发性癫和继发性癫病人之间PHT的平均Cp、Cc、Cs、FCp差别无显著性意义 ,6 2例患者Cc、Cs和FCp三者之间平均浓度比较差别无显著性意义 ;FCp、Cc、Cs三者之间及CP与FCp之间有较好的相关性 ,而CP与Cc、Cs之间相关性不明显。结论 测定Cp并不能较好地反映Cc水平 ,而Cs则可反应FCp和Cc的水平 ,因此可通过测定PHT的Cs水平监测PHT实际抗癫药物浓度。
Objective To investigate the relationship between serum concentration (Cp), cerebrospinal fluid concentration (CSF), salivary fluid concentration (Cs) and serum free concentration (FCp) in patients with PHT treated with epilepsy. Methods The above four kinds of PHT concentrations were detected by immunofluorescence polarization in 62 epilepsy patients with single-phase PHT. Results The mean CpT, Cc, Cs and FCp of PHT between primary epilepsy and secondary epilepsy had no significant difference. There was no significant difference in the average concentrations of Cc, Cs and FCp between the two groups There was a good correlation between FCp, Cc, Cs and between CP and FCp, while the correlation between CP and Cc and Cs was not obvious. Conclusion Cp can not reflect the level of Cc, while Cs can reflect the level of FCp and Cc. Therefore, the actual PHT concentration can be monitored by measuring the level of Cs in PHT.